EFFEXOR  XR- venlafaxine hydrochloride capsule, extended release 
Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.

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Medication Guide

EFFEXOR XR (e-fex-or)
(venlafaxine hydrochloride)
(Extended-Release Capsules)

Read the Medication Guide that comes with EFFEXOR XR before you start taking it and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or treatment. Talk with your healthcare provider if there is something you do not understand or want to learn more about.

What is the most important information I should know about EFFEXOR XR?

EFFEXOR XR and other antidepressant medicines may cause serious side effects, including:

1. Suicidal thoughts or actions:

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency. EFFEXOR XR may be associated with these serious side effects:

2. Serotonin Syndrome
This condition can be life-threatening and may include
:

3. Changes in blood pressure. EFFEXOR XR may:

4. Enlarged pupils (mydriasis).

5. Anxiety and insomnia.

6. Changes in appetite or weight.

7. Manic/hypomanic episodes:

8. Low salt (sodium) levels in the blood. Elderly people may be at greater risk for this.

   Symptoms may include:

9. Seizures or convulsions.

10. Abnormal bleeding: EFFEXOR XR and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAIDs, like ibuprofen or naproxen), or aspirin.

11. Elevated cholesterol.

12. Lung disease and pneumonia: EFFEXOR XR may cause rare lung problems. Symptoms include:

13. Severe allergic reactions:

Do not stop EFFEXOR XR without first talking to your healthcare provider. Stopping EFFEXOR XR too quickly or changing from another antidepressant too quickly may cause serious symptoms including:

What is EFFEXOR XR?

EFFEXOR XR is a prescription medicine used to treat depression. It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider. EFFEXOR XR is also used to treat:

Talk to your healthcare provider if you do not think that your condition is getting better with EFFEXOR XR treatment.

Who should not take EFFEXOR XR?

Do not take EFFEXOR XR if you:

What should I tell my healthcare provider before taking EFFEXOR XR? Ask if you are not sure.

Before starting EFFEXOR XR, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. EFFEXOR XR and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Your healthcare provider or pharmacist can tell you if it is safe to take EFFEXOR XR with your other medicines. Do not start or stop any medicine while taking EFFEXOR XR without talking to your healthcare provider first.

If you take EFFEXOR XR, you should not take any other medicines that contain (venlafaxine) including: venlafaxine HCl.

How should I take EFFEXOR XR?

What should I avoid while taking EFFEXOR XR?

EFFEXOR XR can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how EFFEXOR XR affects you. Do not drink alcohol while using EFFEXOR XR.

What are the possible side effects of EFFEXOR XR?

EFFEXOR XR may cause serious side effects, including:

Common possible side effects in people who take EFFEXOR XR include:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of EFFEXOR XR. For more information, ask your healthcare provider or pharmacist.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088.

How should I store EFFEXOR XR?

Keep EFFEXOR XR and all medicines out of the reach of children.

General information about EFFEXOR XR

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use EFFEXOR XR for a condition for which it was not prescribed. Do not give EFFEXOR XR to other people, even if they have the same condition. It may harm them.

This Medication Guide summarizes the most important information about EFFEXOR XR. If you would like more information, talk with your healthcare provider. You may ask your healthcare provider or pharmacist for information about EFFEXOR XR that is written for healthcare professionals.

For more information about EFFEXOR XR call 1-800-934-5556 or go to www. EFFEXORXR.com.

What are the ingredients in EFFEXOR XR?

Active ingredient: (venlafaxine)

Inactive ingredients:

Extended-Release Capsules: cellulose, ethylcellulose, gelatin, hypromellose, iron oxide, and titanium dioxide

This Medication Guide has been approved by the U.S. Food and Drug Administration for all antidepressants.

This product's label may have been updated. For current full prescribing information, please visit www.pfizer.com

LOGO

LAB-0542-4.0

May 2014

Revised: 6/2014
Document Id: 4ca915df-0780-4f6f-9fb2-f13344cef8a5
Set id: 53c3e7ac-1852-4d70-d2b6-4fca819acf26
Version: 24
Effective Time: 20140610
 
Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.