Instructions for Use

Figure A

Step 2. Attach the Needle

•

Pull off the front cap (See Figure B).

Figure B

•

Unscrew the metal front part from the plastic body by turning the metal front part clockwise (to the right) (See Figure C).

Figure C

•

Peel off the foil from the needle.

•

Push and screw the needle onto the metal front part using the outer needle cover, by turning it counter clockwise (to the left) (See Figure D).

•

Do not remove the outer needle cover and inner needle cap until you are ready to inject.

Figure D

Step 3. Insert the 2-Chamber Cartridge of GENOTROPIN
Use only the 5 mg cartridge.

•

Open the cartridge pack and take out 1 cartridge.

•

Check that the color on the cartridge matches the color around the window of the plastic body (See Figure E).

Figure E

•

Hold the metal front part upright, and insert the cartridge. Insert the end of the cartridge with the metal cap first, as shown (See Figure F).

•

Push the cartridge firmly into place.

Figure F

Step 4. Prepare your Pen

•

Press the red release button. The injection button will pop up (See Figure G).

Figure G

•

Turn the injection button in a counter clockwise direction (to the left) as far as it will go (See Figure H). This will draw back the plunger rod.

Figure H

•

Check that the plunger rod is not visible through the plunger rod window (See Figure I). Do not proceed if the plunger rod is visible, as the medicine will not be properly mixed.

Figure I

Step 5. Mix your GENOTROPIN

•

Make sure that a needle is attached to the metal front part.

•

While holding your pen upright, gently screw the metal front part and the plastic body back together as shown (See Figure J). Make sure that the metal front part is firmly attached to the plastic body. This mixes the liquid and the powder.

Figure J

Step 6. Examine the Solution

•

Gently tip your pen from side to side to help dissolve the powder completely (See Figure K).

Figure K

•

Do not shake your pen, as this might stop the growth hormone from working. Check that the solution (combined growth hormone powder and liquid) is clear in the cartridge window (See Figure L).

•

If you see particles, or if the solution is not clear, do not inject. Remove the cartridge and use a new one.

Figure L

Step 7. Release Trapped Air

•

Remove both the outer needle cover and inner needle cap. Throw away (dispose of) both the inner needle cap and outer needle cover. Do not to touch the exposed needle.

•

Remove any trapped air from the solution as follows:

 

a)

Turn the injection button so that the white mark on the injection button lines up with the black mark on the plastic body (See Figure M).

Figure M

 

b)

Hold your pen with the needle pointing upwards. Gently tap the metal front part with your finger to move any air bubbles to the top.

 

c)

Push the injection button all the way in. You will see a drop of liquid appear at the needle tip. Any trapped air has now been released (See Figure N).

Figure N

 

d)

If you do not see liquid at the needle tip, press the red release button. Then turn the injection button in the direction of the arrow until it clicks 1 time, and the dose display shows '0.1'. Repeat steps b) and c) to remove any trapped air from the solution (see Figure O).

Figure O

Step 8. Attach the Needle Guard (Optional)
The needle guard is intended to hide the needle before, during and after injection and to reduce needle injury. You can choose to use the needle guard, if desired.

•

Grip the sides of the needle guard. Push it over the needle until it snaps in place (See Figure P). Do not push the needle guard on the end.
Be careful not to touch the exposed needle.

Figure P

My daily dose is mg (write in your daily dose)

Step 9. Dial Your Prescribed Dose

•

Press the red release button to reset your pen.

•

The button will pop up and the dose display window will read '0.0'.

•

Turn the injection button in a clockwise direction (to the right) as shown, until your prescribed dose is displayed (See Figure Q).

•

If you turn the button too far, turn it back the other way until your correct dose is displayed.

Figure Q

Step 10. Inject your GENOTROPIN

•

Choose an injection site (thigh, buttocks, or abdomen) as recommended by your healthcare provider. Choose a different site each time you give yourself an injection. Each new injection should be given at least 1 inch from the site you used before (see Figure R).

•

Avoid areas that are bony, bruised, red, sore or hard. You should also avoid areas of the skin that have scars or skin problems.

•

Clean the injection site with the alcohol swab.

•

Allow the injection site to dry.

Figure R

•

Firmly pinch a fold of skin at the injection area. Push the needle fully into the skin fold at a 90° angle as shown (See Figure S).

•

Push the injection button until it clicks. Wait while counting slowly for 5 seconds, and then remove the needle from the skin. This is to make sure that the entire dose has been injected (See Figure S).

Figure S

Step 11. Throw away the Needle and Store your GENOTROPIN PEN 5

•

Pull off the needle guard, gripping the sides. Be careful not to push on the end. (See Figure T).

•

Remove the needle as instructed by your healthcare provider, and throw it away in a sharps disposal container (See Step 14). Do not reuse the needle.

•

Push on the front cap, and put your pen back in its protective case.

•

Store your pen (with the cartridge) in the refrigerator between 36ºF to 46ºF (2ºC to 8ºC) until your next injection.

Figure T

Step 12. Your Next Injection
If you already have a cartridge in your pen, prepare the pen and give the injection as follows:

•

Remove the front cap (See Figure U).

Figure U

•

Make sure there is enough growth hormone solution in the cartridge for your dose. Check the position of the plunger against the indicative scale in the cartridge window (See Figure V).

•

Peel off the foil from a needle.

Figure V

•

Push and screw the needle onto the metal front part of the pen as shown (See Figure W). Remove the outer needle cover and inner needle cap.

•

Follow the instructions above, starting with Step 8: Attach the Needle Guard.

Figure W

Step 13. To Replace the Cartridge

•

Press the red release button to reset your pen (See Figure X).

Figure X

•

Turn the injection button in a counter clockwise direction (to the left) as far as it will go as shown (See Figure Y).This will draw back the plunger rod.

Figure Y

•

Unscrew the metal front part and remove the empty cartridge (See Figure Z).

•

Throw away the empty cartridge as instructed by your healthcare provider.

•

To insert a new cartridge and prepare your pen for reuse, follow the instructions starting with Step 1.

Figure Z

Your pen is supplied with 2 colored clip-on panels, so that you can customize the look of your pen. To remove the clip-on panel from the pen, insert the lip of the front cap into the groove under the front end of the panel, and pry the panel off. The new panel simply clicks into place (See Figure AA).

Figure AA

Figure A

Step 2. Attach the Needle

•

Pull off the front cap (See Figure B).

Figure B

•

Unscrew the metal front part from the plastic body by turning the metal front part clockwise (to the right) (See Figure C).

Figure C

•

Peel off the foil from the needle.

•

Push and screw the needle onto the metal front part using the outer needle cover, by turning it counter clockwise (to the left) (See Figure D).

•

Do not remove the outer needle cover and inner needle cap until you are ready to inject.

Figure D

Step 3. Insert the 2-Chamber Cartridge of GENOTROPIN
Use only the 12 mg cartridge.

•

Open the cartridge pack and take out 1 cartridge.

•

Check that the color on the cartridge matches the color around the window of the plastic body (See Figure E).

Figure E

•

Hold the metal front part upright, and insert the cartridge. Insert the end of the cartridge with the metal cap first, as shown (See Figure F).

•

Push the cartridge firmly into place.

Figure F

Step 4. Prepare the Pen

•

Press the red release button. The injection button will pop up (See Figure G).

Figure G

•

Turn the injection button in a counter clockwise direction (to the left) as far as it will go (See Figure H). This will draw back the plunger rod.

Figure H

•

Check that the plunger rod is not visible through the plunger rod window (See Figure I). Do not proceed if the plunger rod is visible, as the medicine will not be properly mixed.

Figure I

Step 5. Mix your GENOTROPIN

•

Make sure that a needle is attached to the metal front part.

•

While holding your pen upright, gently screw the metal front part and the plastic body back together as shown (See Figure J). Make sure that the metal front part is firmly attached to the plastic body. This mixes the liquid and the powder.

Figure J

Step 6. Examine the Solution

•

Gently tip the pen from side to side to help dissolve the powder completely (See Figure K).

Figure K

•

Do not shake your pen, as this might stop the growth hormone from working. Check that the solution (combined growth hormone powder and liquid) is clear in the cartridge window (See Figure L).

If you see particles, or if the solution is not clear, do not inject. Remove the cartridge and use a new one.

Figure L

Step 7. Release Trapped Air

•

Remove both the outer needle cover and inner needle cap. Throw away (dispose of) both the inner needle cap and outer needle cover. Do not touch the exposed needle.

•

Remove any trapped air from the solution as follows:

 

a)

Turn the injection button so that the white mark on the injection button lines up with the black mark on the plastic body (See Figure M).

Figure M

 

b)

Hold your pen with the needle pointing upwards (See Figure N). Gently tap the metal front part with your finger to move any air bubbles to the top.

Figure N

 

c)

Push the injection button all the way in. You will see a drop of liquid appear at the needle tip. Any trapped air has now been released (See Figure N).

 

d)

If you do not see liquid at the needle tip, press the red release button. Then turn the injection button in the direction of the arrow until it clicks 1 time, and the dose display shows '0.2'. Repeat steps b) and c) to remove any trapped air from the solution (See Figure O).

Figure O

Step 8. Attach the Needle Guard (Optional)
The needle guard is intended to hide the needle before, during and after injection and to reduce needle injury. You can choose to use the needle guard, if desired.

•

Grip the sides of the needle guard. Push it over the needle until it snaps in place (See Figure P). Do not push the needle guard on the end.

Be careful not to touch the exposed needle.

Figure P

My daily dose is mg (write in your daily dose)

Step 9. Dial Your Prescribed Dose

•

Press the red release button to reset your pen.

•

The button will pop up and the dose display window will read '0.0'.

•

Turn the injection button in a clockwise direction (to the right) as shown until your prescribed dose is displayed (See Figure Q).

•

If you turn the button too far, turn it back the other way until your correct dose is displayed.

Figure Q

Step 10. Inject your GENOTROPIN

•

Choose an injection site (thigh, buttocks, or abdomen) as recommended by your healthcare provider. Choose a different site each time you give yourself an injection. Each new injection should be given at least 1 inch from the site you used before (See Figure R).

•

Avoid areas that are bony, bruised, red, sore or hard, and areas of the skin that have scars or skin conditions.

•

Clean the injection site with the alcohol swab.

•

Allow the injection site to dry.

Figure R

•

Firmly pinch a fold of skin at the injection area. Push the needle fully into the skin fold at a 90° angle as shown (See Figure S).

•

Push the injection button until it clicks. Wait while counting slowly for 5 seconds, and then remove the needle from the skin. This is to make sure that the entire dose has been injected (See Figure S).

Figure S

Step 11. Throw away the Needle and Store the GENOTROPIN PEN 12

•

Pull off the needle guard, gripping the sides. Be careful not to push on the end (See Figure T).

•

Remove the needle as instructed by your healthcare provider, and throw it away in a sharps disposal container (See Step 14). Do not reuse the needle.

•

Push on the front cap, and put your pen back in its protective case.

•

Store your pen (with the cartridge) in the refrigerator between 36°F to 46°F (2°C to 8°C) until your next injection.

Figure T

Step 12. Your Next Injection
If you already have a cartridge in your pen, prepare the pen and give the injection as follows:

•

Remove the front cap (See Figure U).

Figure U

•

Make sure there is enough growth hormone solution in the cartridge for your dose. Check the position of the plunger against the indicative scale in the cartridge window (See Figure V).

•

Peel off the foil from a needle.

Figure V

•

Push and screw the needle onto the metal front part of your pen as shown (See Figure W). Remove the outer needle cover and inner needle cap.

•

Follow the instructions above, starting with Step 8: Attach the Needle Guard.

Figure W

Step 13. To Replace the Cartridge

•

Press the red release button to reset your pen (See Figure X).

Figure X

•

Turn the injection button in a counter clockwise direction (to the left) as far as it will go as shown (See Figure Y). This will draw back the plunger rod.

Figure Y

•

Unscrew the metal front part and remove the empty cartridge (See Figure Z).

•

Throw away the empty cartridge as instructed by your healthcare provider.

•

To insert a new cartridge and prepare your pen for reuse, follow the instructions starting with Step 1.

Figure Z

Customizing your Pen
Your pen is supplied with 2 colored clip-on panels, so that you can customize the look of your pen. To remove the clip-on panel from your pen, insert the lip of the front cap into the groove under the front end of the panel, and pry the panel off. The new panel simply clicks into place (See Figure AA).

Figure AA

Step 3.
Wipe the rubber stopper on the GENOTROPIN MINIQUICK with an alcohol pad. (See Figure B)

Figure B

Step 4.
Peel the seal from the back of the injection needle. Leave both the inner needle cover and the outer needle cover on the needle. (See Figure C)

Figure C

Step 5.

•

Attach the needle onto the GENOTROPIN MINIQUICK by pushing it down and turning it clockwise (to the right) until it will no longer turn.

•

Make sure the needle is placed directly over the rubber stopper (not at an angle), before screwing the needle onto the rubber stopper of the GENOTROPIN MINIQUICK. (See Figure D)

Figure D

Step 6.

•

Hold the GENOTROPIN MINIQUICK with the needle pointing up. Turn the plunger rod clockwise (to the right) until it will not go any further. (See Figure E) This will automatically mix the growth hormone powder and the liquid.

•

Do not shake the GENOTROPIN MINIQUICK. Shaking may cause the growth hormone to not work as well.

•

Make sure the solution (combined growth hormone powder and liquid) is clear, and that the growth hormone powder is completely dissolved. If you see particles in the solution, or if the solution is discolored, do not inject it. Call the Pfizer Bridge Program at 1-800-645-1280.

Figure E

Step 7.

•

Choose an injection site (thigh, buttocks, or abdomen) as recommended by your healthcare provider. Choose a different site each time you give yourself an injection. Each new injection should be at least 1 inch from the site you used before (See Figure F).
Avoid areas that are bony, bruised, red, sore or hard. You should also avoid areas that have scars or skin problems.

•

Clean the injection site with the alcohol swab. Allow the injection site to dry.

Figure F

Step 8.

•

Remove the outer needle cover and the inner needle cover from the needle. Save the outer needle cover. (See Figure G)

Figure G

Step 9.

•

Pinch a fold of skin at the injection site firmly, and push the needle straight into the skin at a 90°angle. (See Figure H)

Figure H

Step 10.

•

Push the plunger rod in as far as it will go, to inject all of the medicine in the GENOTROPIN MINIQUICK into the fold of skin. (See Figure I)

•

Wait a few seconds to be sure that all of the growth hormone solution has been injected. Pull out the needle.

Figure I

Step 11

•

Replace the outer needle cover on the needle. (See Figure J)

Figure J