CAVERJECT- alprostadil injection, powder, lyophilized, for solution
Pharmacia & Upjohn Company LLC
for injection, for intracavernosal use
Your healthcare provider should show you how to prepare and inject CAVERJECT the right way before you inject it for the first time. Do not try to inject yourself until you have been shown the right way to give your injections by your healthcare provider.
Information about how to safely inject CAVERJECT:
Supplies you will need to give your CAVERJECT injection (Figure A)
These items are needed for injection and are not supplied with CAVERJECT:
Follow the instructions below to prepare and give your injection. Figure B explains the parts of the needle and syringe that are referred to in the instructions.
CAVERJECT comes in 20 mcg or 40 mcg strengths. Make sure you have the right strength vial of CAVERJECT that your healthcare provider prescribed for you.
Prepare the Syringe
Wash your hands thoroughly and dry them with a clean towel.
Assemble the needle and syringe as follows:
Figure C: Remove the syringe
Keeping hold of the needle assembly, remove the plastic syringe cap from the syringe tip (Figure E). Do not touch the syringe tip.
Figure E: Remove the syringe cap
Hold the needle assembly (still in the paper wrapper). Firmly attach the needle to the syringe tip. Turn it clockwise, like tightening a screw to lock it in place (Figure F).
Figure F: Attach the needle to the syringe
Mixing the powder and liquid to prepare the dose
Remove the plastic cap from the vial of CAVERJECT and remove any cover from the diluent (Figure G).
Wipe the rubber stoppers on the vials of CAVERJECT and diluent with 1 alcohol swab. Throw away the alcohol swab.
Carefully hold the syringe by the barrel and remove the needle cover (Figure H).
Figure H: Remove the needle cover
Hold the syringe with the needle attached and push the needle through the center of the diluent vial's rubber stopper (Figure I). Be careful not to bend the needle.
Figure I: Push the needle into the diluent vial
Figure J: Remove the liquid from the vial
Push the syringe plunger to the 1mL mark on the syringe. This will remove air and extra liquid back into vial.
Figure K: Adjust the amount of liquid in the syringe
Holding the syringe with the needle attached in a straight line with the vial of CAVERJECT, push the needle through the center of the rubber stopper of the vial of CAVERJECT. Be careful not to bend the needle.
Figure L: Push the needle into the CAVERJECT vial
Without removing the needle or touching the needle or stopper, gently swirl (do not shake) the vial until all the powder is dissolved in the liquid. Then turn the vial and needle/syringe upside down and gently swirl the vial to dissolve any powder in the neck of the vial. Do not use the solution if it is cloudy, colored, or contains particles.
Keeping the needle in the vial, firmly hold the vial and syringe upside down in one hand.
Figure M: Remove the liquid from the vial
If there are air bubbles, gently tap the syringe barrel until the bubbles float to the top of the liquid (see Figure N).
Figure N: Tap the syringe barrel to remove air bubbles
Carefully replace the needle used to mix the liquid with a new 29 to 30 gauge one half inch needle for your injection.
Set the syringe down on a level surface.
How to give the injection
The injection will go into the part of the penis shown as the shaded area in Figure O. Do not inject CAVERJECT into the white areas because there may be blood vessels in the white areas. (See Figure P).
Figure P: Cross-section of the penis
Wipe the area for injection with an alcohol swab and let it dry.
Do not throw away the swab; you will need to use it again after you give your injection. (See Step 23).
If your penis is not circumcised, pull the foreskin back. Take hold of the tip of your penis with your thumb and forefinger; stretch it lengthwise along your thigh.
Gently squeeze your penis between your thumb and finger so that the injection site bulges out.
Remove the cover from the needle. Position your penis firmly against your thigh to keep it from moving during the injection.
Keeping a firm grip on your penis, take the syringe in your other hand, and push the needle straight into the selected injection site (See Figure Q).
Figure Q: Insert the needle into the injection site
Holding the syringe barrel between two fingers, move your thumb or finger to the top of the plunger and, with a steady motion, push down on the plunger so that the entire contents of the syringe is slowly injected (Figure R).
Figure R: Inject the contents of the syringe.
After completing the injection, carefully pull the needle out of your penis. Press gently on the injection site with the alcohol swab for about 5 minutes or until bleeding stops.
After your injection:
Dispose of your used CAVERJECT syringe and needles.
How should I store CAVERJECT?
CAVERJECT 20 mcg vial storage information
CAVERJECT 40 mcg vial storage information
Keep CAVERJECT and all medicines out of the reach of children.
This Patient Information and Instructions for Use has been approved by the U.S Food and Drug Administration.
Revised March 2023